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However, some rare side effects of too much vitamin B12 can include: Headache Weakness Nausea Diarrhea Tingling sensations in the hands and feet Allergic reactions or skin rash (uncommon) When To Seek Medical Advice Risk of vitamin B12 deficiency: Groups at a higher risk of vitamin B12 deficiency include older adults, people who only eat plant-based foods (vegans and vegetarians), and those with certain chronic conditions (gastrointestinal disorders that can affect vitamin absorption)

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544 In addition, emerging targets such as IL-36 pathway inhibitors promote Treg cell proliferation by neutralizing the proinflammatory effects of IL-36, and TLR4/MyD88 small molecule inhibitors provide a new way of treating UC by modulating innate immune hyperactivation triggered by colony dysregulation

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