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High homocysteine levels are problematic because they have been linked to heart disease and atherosclerosis.32 In people who are deficient or have mutations in the enzymes that catalyze the production of glutathione from homocysteine, the methylation cycle will be under pressure to remove excess homocysteine

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10.1016/j.bbagen.2012.09.008 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Meister A